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Large hematopoietic stem cell sketch
WELCOME TO THE VO LAB

Designing cell therapies from renewable sources

The Vo lab is located in the Center for Translational Genomics at the Innovative Genomics Institute of UC Berkeley. Our goal is to leverage regenerative cell sources and CRISPR-based genome engineering to advance next-generation cell therapies for blood disorders, cancer and autoimmune disease.

OUR APPROACH

Leverage regenerative potential

We study cells of the blood system, one of the most highly regenerative tissues of the body. Blood is replenished throughout life by a small population of hematopoietic stem cells (HSCs), which reside in the bone marrow. Bone marrow transplant is the most established form of cell therapy and can cure many diseases such as sickle cell anemia, thalassemia, leukemia, lymphoma and primary immunodeficiency. However, the scarcity of primary HSCs limits their clinical use. We leverage the regenerative potential of induced pluripotent stem cells (iPSCs) combined with genome editing technologies to develop cell therapies for hematological disorders, cancer and autoimmune diseases.

Blood disorders icon

CRISPR cures for blood disorders

Developing novel CRISPR delivery modalities to improve therapeutic editing of HSCs.

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T cell fate icon

Genetic and epigenetic regulation of T cell fate

Functional genomics to uncover networks that determine T cell fate.

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Engineering immune cells icon

Engineering immune cells from iPSCs

Generating antigen-specific T cells de novo from renewable stem cell sources.

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WORKING WITH US

Get to know our talented team

We are an interdisciplinary team of stem cell biologists, hematologists, immunologists and genome engineers.

Meet the Team
ANNOUNCEMENTS

Linda becomes the inaugural member of the new Center for Translational Genomics at the IGI!

April 2021

ANNOUNCEMENTS

Linda joins the Gladstone-UCSF Institute of Genomic Immunology as an Affiliate Member!

October 2021

“What if there was a way in which you could go to the hospital and get cancer fighting T-cells in a form where it’s off-the-shelf?”

— Quote from Damon Runyon Cancer Research Fellowship

AFFILIATIONS

We’re proud to partner with

Innovative Genomics Institute LogoThe Berkeley Stem Cell Center LogoJDFR LogoGladstone Logo

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